Rockwell and Spencer will play people desperate for cash and take the job of delivering a human heart from New York to Florida in 24 hours. When they realize the delivery is destined for a black-market buyer who illegally skipped the donor list, they attempt to reroute the heart to its rightful recipient. The pair are soon hunted down by criminals, including the buyer (Janney) who is the drug-dealing ex-boss of Spencer’s character.

Comedy
Nat Faxon
Jim Rash
Octavia Spencer
Sam Rockwell
Allison Janney