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The film follows Saori Kido (Ayaka Sasaki), a young girl troubled by her mysterious powers. She is saved by Pegasus Seiya (Kaito Ishikawa) from an assassin sent to kill her. Saori then learns she is the reincarnation of the Goddess Athena with Seiya being one of her 88 Saints. Upon learning of her destiny, she heads to the Sanctuary and wage war against its Pope. Seiya, alongside fellow Bronze Saints Cygnus Hyōga (Kenshō Ono), Dragon Shiryū (Kenji Akabane), Andromeda Shun (Nobuhiko Okamoto), and Phoenix Ikki (Kenji Nojima) must pass through the twelve Zodiac Temples in Athena's Sanctuary in twelve hours, in order to save their goddess Athena from imminent death. They must confront each of the twelve Gold Saints that guard each of the temples in order to reach the cure that will save Athena.