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Renee Morgan (Noomi Rapace), a single mom who lives with her twelve-year-old son Evan in a quiet suburban home, is terrified of spiders. Unbeknownst to both, their every move is being observed. While running her daily errands her car breaks down and she is violently kidnapped by a group of strangers. About 24 hours later, in an anonymous laboratory, she is tied up and questioned about her medical history, including her great fear of spiders. Soon her captors explain to her that with her genetic abnormality can potentially allow her to "Rupture" in which her own alien nature can be released. Through the experience of one's deepest fear (in Renee's case spiders) causes this transforming her into her true self.