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When a helicopter carrying presidential hopeful Senator William Jefferson crashes in the Quarantine Zone, zombie half-breed Penelope Hope is enlisted into the most unorthodox rescue team ever assembled for a mission to save the very man leading the effort to wipe out her kind from the Plagued States of America... With the recent destruction of Biter's Hill and Biter's Island, the last remaining sanctuary for uninfected humans inside the quarantine zone stands alone against the seemingly endless zombie horde. Tom and Penelope, survivors of the destruction at Biter's Hill, have taken up residence inside the Elevated Platform Station at Biter's Bend in the hopes of rehabilitating Penelope from her half-breed zombie past. Their plans of a normal life are put on hold, however, when Army Ranger Mason Jones arrives seeking asylum from the very man rallying against him, Tom's own father. When Tom's father's helicopter crashes deep inside the quarantine zone, Tom and Penelope enlist Mason Jones and other survivors of Biter's Island on a mission to rescue him.