After an extremist militant group threatens their lives, a young couple (Ryan Phillippe and Mena Suvari) is forced to flee their Christian missionary post in the Kalahari Desert. After being granted passage aboard a rickety plane, piloted by a corrupt smuggler (Emile Hirsch), their escape to safety is nearly in reach. But when their aircraft loses power and crash lands, they discover a bigger threat awaits them as they find themselves stranded in the middle of an animal preserve populated by many hungry maneaters -- lions, leopards, and hyenas. Injured, frightened, and being tracked by the extremists, this ragtag group of passengers must fight for survival from both man and beast where only the strong will survive.